Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10432657 | 0.83 | ESR1 (0.61) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL311714 | 0.83 | HPGD (0.76) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL22806648 | 0.83 | HPGD (0.72) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL4634256 | 0.81 | HPGD (0.73) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL9284336 | 0.80 | HPGD (0.70) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL25186939 | 0.80 | HPGD (0.67) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL3205778 | 0.80 | HPGD (0.67) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL312255 | 0.80 | AKR1C3 (1.00) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL87773 | 0.80 | HPGD (0.67) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 | |
| SCHEMBL1423180 | 0.80 | HPGD (0.67) | HPGDNPC1RAB9ASMN1; SMN2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996031206-A2 | FLAVONES AND COUMARINS AS AGENTS FOR THE TREATMENT OF ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-10-10 | — | — | WO | claimed |
| WO-2011106373-A2 | ARNT ISOFORM 3 AS A PREDICTOR OF AMINOFLAVONE RESPONSIVENESS IN CANCER CELLS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-1996031206-A2 | FLAVONES AND COUMARINS AS AGENTS FOR THE TREATMENT OF ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |