Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.54 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24691381 | 0.90 | GRM5 (0.48) | PRMT5WDR77GRM5NPC1RAB9A | |
| SCHEMBL25786636 | 0.89 | PRMT5 (0.60) | PRMT5WDR77GRM5NPC1RAB9A | |
| SCHEMBL24365834 | 0.87 | GRM5 (0.43) | PRMT5WDR77GRM5SMN1; SMN2RECQL | |
| SCHEMBL24366708 | 0.80 | PRMT5 (0.46) | PRMT5WDR77GRM5RAB9ASMN1; SMN2 | |
| SCHEMBL25955896 | 0.80 | PRMT5 (0.46) | PRMT5WDR77GRM5RAB9ASMN1; SMN2 | |
| SCHEMBL25908271 | 0.78 | GRM5 (0.40) | PRMT5WDR77GRM5SMN1; SMN2RECQL | |
| SCHEMBL24367347 | 0.78 | GRM5 (0.40) | PRMT5GRM5RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL24365211 | 0.77 | PRMT5 (0.60) | PRMT5WDR77GRM5RECQL | |
| SCHEMBL25955903 | 0.77 | GRM5 (0.39) | PRMT5WDR77GRM5NPC1RAB9A | |
| SCHEMBL25908258 | 0.76 | GRM5 (0.42) | PRMT5GRM5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | PRMT5 347/4885WDR77 1263/4885GRM5 2438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.