Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.40 |
| ▸ | CDK1 | P06493 | 9/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.40 |
| ▸ | GSK3B | P49841 | 8/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.37 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365326 | 0.74 | JAK2 (0.40) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL5843496 | 0.70 | JAK2 (0.51) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL152990 | 0.70 | PIP4K2A (0.51) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL29899546 | 0.70 | PIP4K2A (0.51) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL153534 | 0.68 | CCNB2 (0.44) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL6323945 | 0.68 | JAK2 (0.49) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL10710490 | 0.68 | CCNB2 (0.48) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL16090379 | 0.68 | BRD4 (0.52) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL6328115 | 0.68 | CCNB2 (0.58) | JAK2CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL6321462 | 0.68 | CCNB2 (0.48) | JAK2CCNB2CDK1CCNB1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | JAK2 498/4885CCNB2 1440/4885CDK1 1398/4885 |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | JAK2 498/4885CCNB2 1440/4885CDK1 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.