Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21917354 | 0.86 | HTT (0.43) | MAP2K1HTTRECQLALDH1A1LMNA | |
| SCHEMBL1228956 | 0.79 | MAPT (0.50) | MAP2K1HTTRECQLALDH1A1LMNA | |
| SCHEMBL2436615 | 0.77 | MAP2K1 (0.51) | MAP2K1HTTRECQLALDH1A1LMNA | |
| SCHEMBL2434751 | 0.77 | HTT (0.48) | MAP2K1HTTRECQLALDH1A1LMNA | |
| SCHEMBL2441575 | 0.76 | HTT (0.41) | HTTRECQLALDH1A1LMNAPOLB | |
| SCHEMBL21917259 | 0.75 | HTT (0.41) | HTTRECQLALDH1A1LMNAPOLB | |
| SCHEMBL21917263 | 0.74 | MAP2K1 (0.54) | MAP2K1HTTRECQLALDH1A1POLB | |
| SCHEMBL21917165 | 0.74 | HTT (0.48) | HTTRECQLALDH1A1LMNAPOLB | |
| SCHEMBL1230231 | 0.74 | KDM4E (0.52) | MAP2K1HTTRECQLALDH1A1RAB9A | |
| SCHEMBL2436480 | 0.73 | MAPT (0.45) | MAP2K1HTTRECQLALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6989451-B2 | Substituted isothiazole compounds are useful for treating the diseases associated with abnormality in protein kinases(especially MAP kinases) | VALEANT RESEARCH & DEVELOPMENT (US) | 2006-01-24 | — | — | US | claimed |
| EP-2362909-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010039778-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2010-04-08 | — | — | WO | disclosed |