Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | GPR6 | P46095 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23069493 | 0.88 | CA1 (0.46) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL29470221 | 0.88 | CA1 (0.46) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL24371144 | 0.85 | GPR6 (0.40) | GPR6DGAT2DGAT1SOAT1 | |
| SCHEMBL25208574 | 0.84 | CA1 (0.43) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL30474026 | 0.84 | CA1 (0.43) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL24073197 | 0.82 | CA1 (0.42) | CA1CA2HTTHSD17B10TSHR | |
| SCHEMBL26388435 | 0.82 | GABRA1 (0.40) | GPR6GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29545695 | 0.81 | CA1 (0.49) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL24370925 | 0.81 | CA1 (0.49) | CA1CA2GABRA1GABRG2GABRB3 | |
| SCHEMBL24370922 | 0.76 | GPR6 (0.40) | GPR6DGAT2KCNH2DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022084479-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2022-04-28 | — | — | WO | disclosed |