Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373282 | 0.79 | TNKS (0.41) | TNKSPARP1TNKS2KDM4EMAPK14 | |
| SCHEMBL24373805 | 0.74 | HTR2A (0.48) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL24373281 | 0.74 | HTR7 (0.38) | ALDH1A1MAPK14MBNL1 | |
| SCHEMBL29478998 | 0.74 | HTR7 (0.38) | ALDH1A1MAPK14MBNL1 | |
| SCHEMBL29478818 | 0.73 | CTSA (0.32) | ALDH1A1MAPK14SMN1; SMN2HPGDMAPT | |
| SCHEMBL24373286 | 0.73 | CTSA (0.32) | ALDH1A1MAPK14SMN1; SMN2HPGDMAPT | |
| SCHEMBL3530385 | 0.71 | MAPK14 (0.38) | KDM4EALDH1A1MAPK14 | |
| SCHEMBL29478904 | 0.71 | HTR7 (0.42) | PARP1ALDH1A1MAPK14MBNL1 | |
| SCHEMBL24373057 | 0.71 | HTR7 (0.42) | PARP1ALDH1A1MAPK14MBNL1 | |
| SCHEMBL29479084 | 0.70 | MAPT (0.33) | KDM4EALDH1A1MAPK14SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |