Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 3/20 | 0.64 |
| ▸ | MLLT3 | P42568 | 2/20 | 0.64 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24376591 | 0.86 | MLLT3 (0.65) | MLLT1MLLT3MAPK1MAPTTP53 | |
| SCHEMBL24376430 | 0.85 | MLLT1 (0.71) | MLLT1MLLT3MAPTTP53ALDH1A1 | |
| SCHEMBL24376314 | 0.85 | MLLT3 (0.64) | MLLT1MLLT3NOTUMMAPK1MAPT | |
| SCHEMBL27101311 | 0.80 | NOTUM (0.64) | NOTUMMAPK1MAPTTP53ALDH1A1 | |
| SCHEMBL22778855 | 0.79 | NOTUM (0.63) | MLLT1NOTUMMAPK1MAPTTP53 | |
| SCHEMBL17731963 | 0.79 | NOTUM (0.63) | NOTUMMAPK1MAPTTP53ALDH1A1 | |
| SCHEMBL17731965 | 0.79 | MAPK1 (0.80) | NOTUMMAPK1MAPTTP53ALDH1A1 | |
| SCHEMBL29622224 | 0.78 | MLLT3 (0.45) | MLLT1MLLT3NOTUMMAPK1MAPT | |
| SCHEMBL15498742 | 0.74 | TP53 (0.75) | NOTUMMAPK1MAPTTP53ALDH1A1 | |
| SCHEMBL5621967 | 0.74 | NOTUM (0.67) | MLLT1NOTUMMAPK1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |