Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MLLT1 | Q03111 | 7/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | TERT | O14746 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322387 | 0.86 | HTT (0.62) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2325142 | 0.75 | HTT (0.62) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4521824 | 0.75 | HTT (0.62) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL521863 | 0.74 | KDM4E (0.79) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30293592 | 0.74 | MLLT1 (0.67) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL522411 | 0.73 | KDM4E (0.58) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10952871 | 0.72 | HTT (0.58) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL521738 | 0.72 | KDM4E (0.56) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL29368802 | 0.71 | HTT (0.97) | HTTHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL12045417 | 0.71 | HTT (0.97) | HTTHPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |