Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19018205 | 0.87 | NPC1 (0.61) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL24377766 | 0.87 | NPC1 (0.54) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL24377931 | 0.86 | NPC1 (0.60) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL29569817 | 0.85 | NPC1 (0.52) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL24377663 | 0.84 | NPC1 (0.58) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL29568685 | 0.83 | MAPK1 (0.45) | NPC1RAB9AMAPK1TP53MAPT | |
| SCHEMBL1680448 | 0.82 | NPC1 (0.66) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL30546579 | 0.80 | NPC1 (0.64) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL16269097 | 0.80 | NPC1 (0.64) | NPC1RAB9ANPSR1MAPK1DCTPP1 | |
| SCHEMBL21724017 | 0.79 | NPC1 (0.62) | NPC1RAB9ANPSR1MAPK1DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022084990-A1 | METHODS FOR THE PREPARATION OF PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND INTERMEDIATES USED THEREIN | ADAMA MAKHTESHIM LTD. (IL) | 2022-04-28 | — | — | WO | disclosed |