Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563106 | 1.00 | TYK2 (0.47) | TYK2JAK2NOS3NOS2NOS1 | |
| SCHEMBL29562794 | 0.83 | TYK2 (0.45) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL29562754 | 0.83 | TYK2 (0.45) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL21329689 | 0.83 | TYK2 (0.45) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL21329691 | 0.83 | TYK2 (0.45) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL21330284 | 0.83 | TYK2 (0.45) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL24377850 | 0.79 | TYK2 (0.48) | TYK2JAK2ALOX5JAK1 | |
| SCHEMBL29017822 | 0.77 | TYK2 (0.48) | TYK2JAK2ALOX5JAK1KDM4E | |
| SCHEMBL29563122 | 0.76 | TYK2 (0.72) | TYK2JAK2JAK1 | |
| SCHEMBL29563074 | 0.76 | TYK2 (0.72) | TYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249526-A | TYK2 selective inhibitors and uses thereof | 南京药石科技股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |