Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.50 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12135841 | 0.89 | GAA (0.51) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL23167800 | 0.89 | CYP3A4 (0.62) | GAAPOLBCYP3A4USP2MAPK1 | |
| Methyl 2,4,6-Trimethoxybenzoate SCHEMBL2563067 | 0.88 | CYP3A4 (0.58) | GAACYP3A4USP2MAPK1SMN1; SMN2 | |
| SCHEMBL205044 | 0.83 | KDM4E (0.50) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL21957666 | 0.81 | CYP3A4 (0.71) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL2027170 | 0.81 | CYP3A4 (0.69) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL6945356 | 0.81 | GAA (0.50) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL20812825 | 0.81 | POLB (0.71) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL3783006 | 0.81 | KDM4E (0.49) | GAAPOLBCYP3A4USP2MAPK1 | |
| SCHEMBL9595637 | 0.81 | POLB (0.59) | GAAPOLBCYP3A4USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |