Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CASP9 | P55211 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379419 | 0.79 | BRD4 (0.39) | ACHETSHRBRD4CREBBPEP300 | |
| SCHEMBL14157895 | 0.74 | ACHE (0.63) | ACHETSHRMETAP1 | |
| SCHEMBL20128633 | 0.74 | ACHE (0.49) | ACHETSHRHTR2AHTR2CHTR2B | |
| SCHEMBL22151224 | 0.73 | ACHE (0.43) | ACHETSHRMETAP1CASP7 | |
| SCHEMBL20128664 | 0.71 | ACHE (0.49) | ACHETSHRMETAP1NOS3TDP2 | |
| SCHEMBL11776080 | 0.68 | ACHE (0.61) | ACHETSHRMETAP1NOS3NOS2 | |
| SCHEMBL16691536 | 0.68 | ACHE (0.66) | ACHETSHRMETAP1NOS3NOS2 | |
| SCHEMBL7939001 | 0.68 | ACHE (0.65) | ACHETSHRMETAP1HTR2AHTR2C | |
| SCHEMBL3054005 | 0.68 | ACHE (0.66) | ACHETSHRMETAP1NOS3NOS2 | |
| SCHEMBL9752693 | 0.67 | ACHE (1.00) | ACHETSHRMETAP1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |