Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.69 |
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.55 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24828772 | 0.91 | CRBN (0.69) | CRBNGSPT1IKZF3 | |
| SCHEMBL24414401 | 0.90 | CRBN (0.68) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL31554613 | 0.87 | CRBN (0.62) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL25228921 | 0.87 | CRBN (0.70) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL28737958 | 0.87 | CRBN (0.67) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL23657087 | 0.87 | CRBN (0.64) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL24600532 | 0.86 | CRBN (0.69) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL25469611 | 0.86 | CRBN (0.69) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL25234569 | 0.86 | CRBN (0.69) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL24991511 | 0.86 | CRBN (0.72) | CRBNIKZF2GSPT1DDB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022098544-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |