Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.69 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379439 | 0.91 | CRBN (0.69) | CRBNGSPT1IKZF3 | |
| SCHEMBL24250681 | 0.90 | CRBN (0.68) | CRBNGSPT1 | |
| SCHEMBL23683349 | 0.87 | CRBN (0.64) | CRBNGSPT1 | |
| SCHEMBL26091035 | 0.87 | CRBN (0.67) | CRBNGSPT1 | |
| SCHEMBL26739486 | 0.86 | CRBN (0.66) | CRBNGSPT1IKZF3 | |
| SCHEMBL19503721 | 0.86 | CRBN (0.69) | CRBNGSPT1 | |
| SCHEMBL29739304 | 0.86 | CRBN (0.72) | CRBNGSPT1 | |
| SCHEMBL30373130 | 0.86 | CRBN (0.72) | CRBNGSPT1IKZF3 | |
| SCHEMBL21906691 | 0.86 | CRBN (0.72) | CRBNGSPT1IKZF3 | |
| SCHEMBL24501690 | 0.86 | CRBN (0.69) | CRBNGSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542251-B2 | IRAK degraders and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11542251-B2 | IRAK degraders and uses thereof | IRAK2, IRAK1, IRAK4 | CRBN 158/4885GSPT1 2641/4885IKZF3 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.