Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21106666 | 1.00 | PIK3CD (0.38) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL22837733 | 1.00 | PIK3CD (0.38) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL22861841 | 0.90 | PIK3CD (0.35) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL22861935 | 0.90 | PIK3CD (0.35) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL22848948 | 0.88 | HRH3 (0.37) | PIK3CD | |
| SCHEMBL21106200 | 0.88 | PIK3CD (0.38) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL22856067 | 0.88 | HRH3 (0.37) | PIK3CD | |
| SCHEMBL21105851 | 0.88 | PIK3CD (0.38) | PIK3CDKDM4EALDH1A1TDP1 | |
| SCHEMBL26465870 | 0.88 | HRH3 (0.37) | PIK3CD | |
| SCHEMBL24509130 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807636-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-11318205-B1 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807636-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | PIK3CD 321/4885KDM4E 190/4885ALDH1A1 2776/4885 |
| US-11318205-B1 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | PIK3CD 321/4885KDM4E 190/4885ALDH1A1 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.