Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438128 | 0.86 | UGT1A1 (0.49) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL8481817 | 0.86 | ATM (0.57) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL2059402 | 0.86 | ATM (0.57) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL8947270 | 0.86 | ATM (0.57) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL2440555 | 0.82 | ATM (0.48) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL2440558 | 0.82 | ATM (0.48) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL3805582 | 0.82 | ATM (0.55) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL3805577 | 0.82 | ATM (0.55) | ATMCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL3695644 | 0.82 | ATM (0.68) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL7301095 | 0.78 | ATM (0.62) | ATMCTSSCTSKPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697344-B1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LAB (US) | 2011-09-28 | — | — | EP | disclosed |
| US-7834043-B2 | Prevent reproduct of aids virus | ABBOTT LABORATORIES (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100249181-A1 | HIV Protease Inhibiting Compounds | ABBOTT LABORATORIES (US) | 2010-09-30 | — | — | US | disclosed |
| US-20050148623-A1 | Prevent reproduct of aids virus | ABBVIE INC. | 2005-07-07 | — | — | US | disclosed |
| US-20050131017-A1 | HIV protease inhibiting compounds | ABBOTT LABORATORIES | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148623-A1 | Prevent reproduct of aids virus | SERPINB1, PRSS1, SERPINA3 | ATM 2476/4885CTSS 69/4885CTSK 204/4885 |
| US-20050131017-A1 | HIV protease inhibiting compounds | SERPINB1, HPN, DNPEP | ATM 4055/4885CTSS 62/4885CTSK 76/4885 |
| US-20100249181-A1 | HIV Protease Inhibiting Compounds | SERPINB1, HPN, DNPEP | ATM 4055/4885CTSS 62/4885CTSK 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.