Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 10/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24384611 | 0.78 | PRKDC (0.52) | PRKDCPIK3CDPIK3CAPIK3CBCNR2 | |
| SCHEMBL24384618 | 0.76 | PRKDC (0.50) | PRKDCPIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL26604580 | 0.74 | PRKDC (0.47) | PRKDCPIK3CDPIK3CAPIK3CBCNR2 | |
| SCHEMBL24384624 | 0.73 | PRKDC (0.52) | PRKDCPIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL14972404 | 0.72 | PRKDC (0.49) | PRKDCPIK3CDPIK3CAPIK3CBLRRK2 | |
| SCHEMBL2419958 | 0.72 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL31302329 | 0.72 | PRKDC (0.52) | PRKDCPIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL2421027 | 0.72 | PRKDC (0.52) | PRKDCPIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL30493084 | 0.71 | C1S (0.58) | PRKDCSOS1TP53MAPTALOX15 | |
| SCHEMBL9864307 | 0.71 | MAPT (0.65) | CNR2LGMNNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3992189-A1 | QUINAZOLINE AND CINNOLINE DERIVATIVES AS DNA-PK INHIBITOR | Medshine Discovery Inc. (CN) | 2022-05-04 | — | — | EP | disclosed |