Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 5/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 5/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | CD63 | P08962 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27180734 | 0.88 | HCRTR2 (0.55) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL24529266 | 0.88 | HCRTR2 (0.55) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL29102774 | 0.81 | HCRTR2 (0.41) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL24387093 | 0.81 | HCRTR2 (0.41) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL24386985 | 0.81 | EPHB4 (0.41) | HCRTR2EPHB4AURKASYKCD63 | |
| Hydrochloric Acid SCHEMBL29749900 | 0.81 | HCRTR2 (0.41) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL27181588 | 0.80 | HCRTR2 (0.53) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL24529309 | 0.80 | HCRTR2 (0.53) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL24387336 | 0.78 | HCRTR2 (0.35) | HCRTR2EPHB4AURKASYKCD63 | |
| SCHEMBL29749749 | 0.78 | HCRTR2 (0.55) | HCRTR2EPHB4AURKASYKTMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236938-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116600803-A | Macrocyclic urea orexin receptor agonists | 默沙东有限责任公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |