Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 10/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | CD63 | P08962 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529142 | 0.87 | HCRTR2 (0.46) | EPHB4AURKASYKCD63HCRTR2 | |
| SCHEMBL24386988 | 0.82 | ALDH1A1 (0.38) | SYKCD63HCRTR2POLB | |
| SCHEMBL24386982 | 0.81 | HCRTR2 (0.44) | EPHB4AURKASYKCD63HCRTR2 | |
| SCHEMBL24529311 | 0.79 | HCRTR2 (0.45) | EPHB4AURKASYKCD63HCRTR2 | |
| SCHEMBL27180200 | 0.77 | HCRTR2 (0.45) | EPHB4AURKASYKCD63HCRTR2 | |
| SCHEMBL24529307 | 0.77 | AURKA (0.48) | EPHB4PDPK1AURKASYKCD63 | |
| SCHEMBL24386989 | 0.75 | HCRTR2 (0.41) | SYKCD63HCRTR2 | |
| SCHEMBL24529671 | 0.74 | HCRTR2 (0.47) | EPHB4AURKASYKCD63HCRTR2 | |
| SCHEMBL2897650 | 0.73 | SYK (0.73) | SYKCD63 | |
| SCHEMBL24529319 | 0.72 | SYK (0.40) | EPHB4AURKASYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |