Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 7/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 7/20 | 0.34 |
| ▸ | CD63 | P08962 | 2/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29102897 | 1.00 | HCRTR2 (0.47) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24529568 | 0.89 | HCRTR2 (0.57) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24386929 | 0.83 | HCRTR2 (0.49) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24386983 | 0.83 | HCRTR2 (0.48) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL29750202 | 0.83 | HCRTR2 (0.48) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24387056 | 0.82 | HCRTR2 (0.34) | HCRTR2 | |
| Hydrochloric Acid SCHEMBL29750119 | 0.82 | HCRTR2 (0.33) | HCRTR2 | |
| SCHEMBL29749888 | 0.81 | HCRTR2 (0.44) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24387658 | 0.81 | HCRTR2 (0.52) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24387380 | 0.80 | HCRTR2 (0.39) | HCRTR2PDE3BPDE3ASYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236938-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116600803-A | Macrocyclic urea orexin receptor agonists | 默沙东有限责任公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |