Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | THPO | P40225 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL26965348 | 0.98 | SCN10A (0.41) | SCN10ASCN5AHRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27127616 | 0.98 | SCN10A (0.41) | SCN10ASCN5AHRH4HRH3ALDH1A1 | |
| SCHEMBL19859619 | 0.78 | HRH4 (0.35) | HRH4HRH3ALDH1A1NFKB1THPO | |
| SCHEMBL19859621 | 0.78 | HRH4 (0.35) | HRH4HRH3ALDH1A1NFKB1THPO | |
| SCHEMBL17321282 | 0.73 | AAK1 (0.33) | ALDH1A1AAK1 | |
| SCHEMBL15618861 | 0.72 | SCN5A (0.30) | SCN10ASCN5A | |
| SCHEMBL22911357 | 0.72 | PDE9A (0.30) | — | |
| SCHEMBL24387815 | 0.71 | SCN10A (0.46) | SCN10ASCN5ACYP3A4AAK1 | |
| Hydrochloric Acid SCHEMBL15618485 | 0.71 | LMNA (0.31) | ALDH1A1LMNAGMNNMAPTPMP22 | |
| SCHEMBL15618332 | 0.71 | CYP3A4 (0.41) | NFKB1THPOANPEPERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022093856-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-05-05 | — | — | WO | disclosed |