Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 5/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | JAK2 | O60674 | 4/20 | 0.61 |
| ▸ | JAK1 | P23458 | 3/20 | 0.61 |
| ▸ | TYK2 | P29597 | 2/20 | 0.61 |
| ▸ | TTK | P33981 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | JAK3 | P52333 | 8/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 4/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | BMX | P51813 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29537572 | 0.91 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL29537573 | 0.91 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL24392702 | 0.91 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL24392718 | 0.89 | MAP3K7 (0.71) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL16514904 | 0.85 | JAK2 (0.69) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL24392882 | 0.82 | MAP3K7 (0.63) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL16513651 | 0.80 | MAP3K7 (0.78) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL24392701 | 0.79 | MAP3K7 (0.71) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL29538046 | 0.79 | MAP3K7 (0.71) | MAP3K7MAP2K1MAPK1FLT3JAK2 | |
| SCHEMBL16513883 | 0.79 | JAK2 (0.80) | JAK2JAK1TYK2TTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116685583-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-01 | — | — | CN | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |