SCHEMBL24398481

SCHEMBL24398481

Cc1noc(C)c1-c1cc(NC(=O)c2cc(Cl)ccn2)ccc1OCCN1CCCC1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.53
HTR2C P28335 19/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29619098 1.00 HTR2A (0.53) HTR2AHTR2C
SCHEMBL29619150 0.91 HTR2A (0.52) HTR2AHTR2C
SCHEMBL24398358 0.91 HTR2A (0.52) HTR2AHTR2C
SCHEMBL24398570 0.86 HTR2A (0.59) HTR2AHTR2C
SCHEMBL29619076 0.85 HTR2A (0.57) HTR2AHTR2C
SCHEMBL29619146 0.83 LMNA (0.49) HTR2AHTR2C
SCHEMBL29619092 0.83 HTR2A (0.55) HTR2AHTR2C
SCHEMBL31199005 0.83 MCHR1 (0.55) HTR2AHTR2C
SCHEMBL29619051 0.83 HTR2A (0.51) HTR2AHTR2C
SCHEMBL29619032 0.83 HTR2A (0.48) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022093850-A1 ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2022-05-05 WO disclosed