Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | USP2 | O75604 | 7/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30402343 | 1.00 | AURKA (0.55) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL30401990 | 0.92 | AURKA (0.55) | AURKARPS6KB1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24399559 | 0.92 | AURKA (0.55) | AURKARPS6KB1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL27902365 | 0.88 | AURKA (0.55) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL1461787 | 0.86 | AURKA (0.71) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL30401701 | 0.86 | AURKA (0.71) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL1462982 | 0.83 | AURKA (0.53) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL25376065 | 0.83 | AURKA (0.50) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL24399771 | 0.82 | KDM4C (0.52) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 | |
| SCHEMBL30401719 | 0.82 | KDM4C (0.52) | AURKARPS6KB1KDM4CCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312556-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-10-05 | — | — | US | disclosed |
| US-20230312556-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-10-05 | — | — | US | disclosed |
| US-20230312556-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-10-05 | — | — | US | disclosed |
| EP-4238967-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| EP-4238967-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| CN-116096718-A | Aryl amide compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312556-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | AHR, ARNT, NOTUM | AURKA 2128/4885RPS6KB1 4099/4885KDM4C 2135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.