Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 13/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22436421 | 0.84 | KMT2A (0.42) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL29839314 | 0.84 | KMT2A (0.45) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL30414024 | 0.82 | KMT2A (0.37) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL1762639 | 0.82 | AAK1 (0.33) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL25028822 | 0.82 | KMT2A (0.40) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL2439434 | 0.82 | SMN1; SMN2 (0.46) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL30908527 | 0.81 | MAPK1 (0.44) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL796491 | 0.80 | CYP2C19 (0.46) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL16828692 | 0.80 | KMT2A (0.39) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL18248722 | 0.79 | KMT2A (0.43) | KMT2AMEN1GAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-B1 | 2,3 DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER (US) | 2015-11-04 | — | — | EP | disclosed |
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | PFIZER INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8609680-B2 | 2,3-dihydro-1H-inden-1-yl-2,7-diazaspiro[3.5] nonane derivatives | PFIZER INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | PFIZER INC. | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | GIPR, GLP1R, GHSR | KMT2A 2302/4885MEN1 1344/4885GAA 2066/4885 |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | GIPR, GLP1R, GHSR | KMT2A 2320/4885MEN1 1300/4885GAA 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.