Nobiletin

Nobiletin

SCHEMBL244029

COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 1.00
CYP3A4 P08684 4/20 1.00
ABCB1 P08183 4/20 1.00
ABCG2 Q9UNQ0 4/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
MAPT P10636 2/20 1.00
MAPK1 P28482 2/20 1.00
KDM4E B2RXH2 1/20 1.00
HPGD P15428 1/20 1.00
HSD17B10 Q99714 1/20 1.00
USP2 O75604 1/20 0.81
LMNA P02545 1/20 0.81
ELANE P08246 1/20 0.81
TP53 P04637 1/20 0.71
MDM2 Q00987 1/20 0.71
PKM P14618 1/20 0.71
CYP1A1 P04798 2/20 0.62
CYP1A2 P05177 2/20 0.62
CYP1B1 Q16678 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nobiletin SCHEMBL29374681 1.00 ALDH1A1 (1.00) ALDH1A1CYP3A4ABCB1ABCG2MEN1
Nobiletin SCHEMBL22092292 1.00 ALDH1A1 (1.00) ALDH1A1CYP3A4ABCB1ABCG2MEN1
Nobiletin SCHEMBL30049859 1.00 ALDH1A1 (1.00) ALDH1A1CYP3A4ABCB1ABCG2MEN1
Nobiletin SCHEMBL30049905 1.00 ALDH1A1 (1.00) ALDH1A1CYP3A4ABCB1ABCG2MEN1
SCHEMBL25383379 0.90 ALDH1A1 (0.82) ALDH1A1CYP3A4ABCB1ABCG2MEN1
5-Demethylnobiletin SCHEMBL31237479 0.90 ALDH1A1 (1.00) ALDH1A1CYP3A4ABCB1ABCG2MEN1
SCHEMBL25225757 0.90 ALDH1A1 (0.82) ALDH1A1CYP3A4ABCB1ABCG2MEN1
SCHEMBL29611717 0.90 ALDH1A1 (0.81) ALDH1A1CYP3A4ABCB1ABCG2MEN1
SCHEMBL25263457 0.90 ALDH1A1 (0.86) ALDH1A1CYP3A4ABCB1ABCG2MEN1
SCHEMBL28787165 0.90 ALDH1A1 (0.81) ALDH1A1CYP3A4ABCB1ABCG2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4977 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122081102-A Microbial strain for de novo synthesis of gardenia flavin B and application of microbial strain in production of polymethoxy flavonoid compound 2026-05-26 CN claimed
CN-122063217-A Quality transmission quality control method for whole preparation process of qi-tonifying, nerve-soothing and mass-eliminating mixture 江苏省中医院 2026-05-19 CN claimed
CN-122056926-A Probiotic composition containing melatonin and application of composition in sleep 南京北极光生物科技有限公司 2026-05-19 CN claimed
CN-122056871-A Application of nobiletin in preparation of drugs for activating aromatic hydrocarbon receptor pathway 华南农业大学 2026-05-19 CN claimed
CN-122006289-A Green technology for extracting natural ingredients of dried orange peel by water and application of green technology in beverage 泛亚香料(武汉)科技股份有限公司 2026-05-12 CN claimed
CN-122005744-A Quality marker for preventing and treating kidney-yang deficiency by using medicinal and edible formula composition, and preparation method and application thereof 广西壮族自治区中医药研究院 2026-05-12 CN claimed
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECH INC (US) 2026-04-09 US claimed
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
US-20250381207-A1 FLAVONOID-CONTAINING COMPOSITIONS AND TREATMENT OF VIRAL DISEASES WITH SAME AMH Biotech LLC (US) 2025-12-18 US claimed
US-20250367206-A1 1-METHYLXANTHINE-BASED BIOACTIVE COMPOSITION AND METHOD OF USE THEREOF Ingenious Ingredients, LP (US) 2025-12-04 US claimed
EP-1109548-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING BONE DISEASES USING TOCOTRIENOLS LIPOGENICS, INCORPORATED (US) 2001-06-27 EP claimed
US-6239114-B1 TRITERPENE DERIVATIVES, ANTITUMOR KGK SYNERGIZE (CA) 2001-05-29 US claimed
WO-2001032160-A2 MODIFICATION OF CHOLESTEROL CONCENTRATIONS WITH CITRUS PHYTOCHEMICALS TROPICANA PRODUCTS, INC. (US) 2001-05-10 WO claimed
WO-2001019383-A1 STABLE CAROTENE-XANTHOPHYLL BEADLET COMPOSITIONS AND METHODS OF USE ALCON, INC. (CH) 2001-03-22 WO claimed
US-6184246-B1 Inhibition of cytokine production by polymethoxylated flavones THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE 2001-02-06 US claimed
WO-2000002553-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING BONE DISEASES USING TOCOTRIENOLS LIPOGENICS, INC. (US) 2000-01-20 WO claimed
EP-0605261-B1 Use of a flavone derivative as taste modifier and a method of modifying taste SAN EI GEN FFI INC (JP) 1999-09-15 EP claimed
EP-0938851-A2 Beverage and process for preparing it Eckes-Granini GmbH & Co. Kommanditgesellschaft (DE) 1999-09-01 EP claimed
US-5580545-A ADDING FLAVONE DERIVATIVES TO FOODS, BEVERAGES OR TOILETRIES TO ENHANCE OR REDUCE FLAVORS SAN-EI GEN F.F.I., INC. (JP) 1996-12-03 US claimed
EP-0605261-A2 A taste modifier and a method of modifying taste SAN-EI GEN F.F.I., INC. (JP) 1994-07-06 EP claimed