Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 16/20 | 0.36 |
| ▸ | JAK2 | O60674 | 9/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23192445 | 0.85 | AXL (0.41) | JAK3RETFGFR1LTKGRK5 | |
| SCHEMBL20283374 | 0.82 | JAK1 (0.46) | JAK3AXLPRKCIJAK1JAK2 | |
| SCHEMBL12424042 | 0.82 | JAK1 (0.46) | JAK3AXLPRKCIJAK1JAK2 | |
| SCHEMBL20290071 | 0.78 | JAK1 (0.36) | JAK3AXLPRKCIJAK1JAK2 | |
| SCHEMBL20289774 | 0.76 | JAK3 (0.41) | JAK3RETFGFR1LTKGRK5 | |
| SCHEMBL29588119 | 0.74 | PRKCI (0.47) | JAK3RETFGFR1LTKGRK5 | |
| SCHEMBL12424590 | 0.74 | PRKCI (0.47) | JAK3RETFGFR1LTKGRK5 | |
| SCHEMBL28735162 | 0.74 | PRKCI (0.40) | JAK3RETFGFR1LTKGRK5 | |
| SCHEMBL29587459 | 0.72 | JAK1 (0.33) | JAK3AXLPRKCIJAK1JAK2 | |
| SCHEMBL30822865 | 0.72 | CYP2C9 (0.36) | JAK3RETFGFR1LTKGRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515913-B1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2022-05-11 | — | — | EP | disclosed |