Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.33 |
| ▸ | JAK2 | O60674 | 9/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23192445 | 0.78 | AXL (0.41) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL20283374 | 0.76 | JAK1 (0.46) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL12424042 | 0.76 | JAK1 (0.46) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL24404372 | 0.72 | JAK3 (0.40) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL20290071 | 0.72 | JAK1 (0.36) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL30822865 | 0.71 | CYP2C9 (0.36) | JAK1JAK2JAK3 | |
| SCHEMBL29588684 | 0.71 | CYP2C19 (0.35) | — | |
| SCHEMBL12424590 | 0.68 | PRKCI (0.47) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL29588119 | 0.68 | PRKCI (0.47) | JAK1JAK2TYK2JAK3AXL | |
| SCHEMBL24642433 | 0.67 | JAK1 (0.45) | JAK1JAK2TYK2JAK3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478528-A | Aroyl-substituted tricyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2022-05-13 | — | — | CN | disclosed |