Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.57 |
| ▸ | VEGFA | P15692 | 4/20 | 0.57 |
| ▸ | FLT1 | P17948 | 4/20 | 0.57 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920951 | 0.88 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL1921233 | 0.83 | EGLN1 (0.66) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL29563203 | 0.83 | EGLN1 (0.66) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL15485973 | 0.78 | EGLN1 (0.55) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL16181326 | 0.78 | EGLN1 (0.48) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL23199578 | 0.78 | EGLN1 (0.63) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL23501734 | 0.78 | EGLN1 (0.73) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL13095592 | 0.78 | EGLN1 (0.62) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL14150780 | 0.77 | EGLN1 (0.47) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL14150782 | 0.77 | EGLN1 (0.47) | EGLN1VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357911-B1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | AKEBIA THERAPEUTICS INC (US) | 2022-05-11 | — | — | EP | disclosed |