Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 15/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 11/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 11/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 9/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.42 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.42 |
| ▸ | BMP4 | P12644 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.40 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24409701 | 0.92 | ACVR1 (0.45) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409663 | 0.91 | ACVR1 (0.46) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409776 | 0.90 | KDR (0.50) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL17442261 | 0.84 | ACVR1 (0.63) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409611 | 0.79 | ACVR1 (0.48) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409629 | 0.79 | ACVR1 (0.59) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409703 | 0.78 | ACVR1 (0.46) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409682 | 0.77 | ACVR1 (0.64) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL23988925 | 0.77 | ACVR1 (0.46) | ACVR1KDRTGFBR1PRKAB1BMPR1B | |
| SCHEMBL24409783 | 0.77 | ACVR1 (0.55) | ACVR1KDRTGFBR1PRKAB1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081212-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2022099166-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098812-A1 | METHODS OF TREATING IRON OVERLOAD | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098821-A1 | METHODS OF TREATING LYMPHOPENIA | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |