Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 19/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387071 | 0.84 | AXL (0.77) | AXLMETKCNH2 | |
| SCHEMBL2384942 | 0.83 | MET (0.61) | AXLMETKCNH2GRK2GRK5 | |
| SCHEMBL2385095 | 0.81 | MET (0.68) | AXLMETKCNH2GRK2GRK5 | |
| SCHEMBL3474312 | 0.78 | AXL (0.80) | AXLMETKCNH2 | |
| SCHEMBL27829982 | 0.75 | MET (0.59) | AXLMETKCNH2GRK2GRK5 | |
| SCHEMBL2386910 | 0.74 | MET (0.64) | AXLMETKCNH2 | |
| SCHEMBL27848370 | 0.74 | MET (0.64) | AXLMETKCNH2 | |
| SCHEMBL12329690 | 0.74 | AXL (0.61) | AXLMETKCNH2 | |
| SCHEMBL27848452 | 0.73 | AXL (0.74) | AXLMETKCNH2 | |
| SCHEMBL2441742 | 0.73 | MET (0.54) | METGRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |