Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557803 | 1.00 | HTR2C (0.39) | HTR2CHIF1ANPSR1RXFP1AGTR1 | |
| SCHEMBL24416911 | 0.96 | HTR2C (0.38) | HTR2CHIF1ANPSR1RXFP1AGTR1 | |
| SCHEMBL29557035 | 0.96 | HTR2C (0.38) | HTR2CHIF1ANPSR1RXFP1AGTR1 | |
| SCHEMBL28778336 | 0.93 | HTR2C (0.39) | HTR2CHIF1ANPSR1RXFP1AGTR1 | |
| SCHEMBL24417223 | 0.83 | SMN1; SMN2 (0.40) | ALDH1A1LMNA | |
| SCHEMBL24416993 | 0.83 | CCR3 (0.35) | CCR3ALDH1A1 | |
| SCHEMBL29557058 | 0.83 | CCR3 (0.35) | CCR3ALDH1A1 | |
| SCHEMBL24416864 | 0.83 | HIF1A (0.45) | HTR2CHIF1ANPSR1RXFP1CCR3 | |
| SCHEMBL24416865 | 0.83 | SMN1; SMN2 (0.32) | HTR2CHIF1ANPSR1RXFP1TSHR | |
| SCHEMBL29557220 | 0.83 | SMN1; SMN2 (0.32) | HTR2CHIF1ANPSR1RXFP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114436985-A | Tetrazole derivative, preparation method thereof, pharmaceutical composition containing tetrazole derivative and application of pharmaceutical composition | 浙江大学 | 2022-05-06 | — | — | CN | claimed |
| CN-112457265-A | Tetrazole derivative, preparation method thereof, pharmaceutical composition containing tetrazole derivative and application of pharmaceutical composition | 浙江大学 | 2021-03-09 | — | — | CN | claimed |
| WO-2022095965-A1 | TETRAZOLE DERIVATIVE, PREPARATION FOR TETRAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING TETRAZOLE DERIVATIVE, AND APPLICATION OF TETRAZOLE DERIVATIVE | 浙江大学 | 2022-05-12 | — | — | WO | disclosed |
| CN-114436985-A | Tetrazole derivative, preparation method thereof, pharmaceutical composition containing tetrazole derivative and application of pharmaceutical composition | 浙江大学 | 2022-05-06 | — | — | CN | disclosed |
| CN-112457265-A | Tetrazole derivative, preparation method thereof, pharmaceutical composition containing tetrazole derivative and application of pharmaceutical composition | 浙江大学 | 2021-03-09 | — | — | CN | disclosed |