Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937836 | 0.86 | CYP3A4 (0.49) | CYP3A4TDP1KDM4ENPC1MAPT | |
| SCHEMBL29672768 | 0.82 | MEN1 (0.46) | CYP3A4TDP1MAPTSUCNR1DRD2 | |
| SCHEMBL24418340 | 0.82 | MEN1 (0.46) | CYP3A4TDP1MAPTSUCNR1DRD2 | |
| SCHEMBL23469615 | 0.80 | TDP1 (0.41) | CYP3A4TDP1KDM4ENPC1MAPT | |
| SCHEMBL39993 | 0.80 | CYP3A4 (0.52) | CYP3A4TDP1KDM4ECA12CA1 | |
| SCHEMBL24418750 | 0.80 | SUCNR1 (0.45) | SUCNR1DRD2CA12CA1CA2 | |
| SCHEMBL29672755 | 0.80 | SUCNR1 (0.45) | SUCNR1DRD2CA12CA1CA2 | |
| SCHEMBL24418319 | 0.79 | SUCNR1 (0.44) | CYP3A4TDP1MAPTSUCNR1DRD2 | |
| SCHEMBL29672783 | 0.79 | SUCNR1 (0.44) | CYP3A4TDP1MAPTSUCNR1DRD2 | |
| SCHEMBL29316553 | 0.79 | MAPT (0.49) | CYP3A4NPC1MAPTRAB9ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. | 2024-07-18 | — | — | US | disclosed |
| WO-2023144723-A1 | IMMUNOCONJUGATES COMPRISING KALLIKREIN RELATED PEPTIDASE 2 ANTIGEN BINDING DOMAINS AND THEIR USES | JANSSEN BIOTECH, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| US-20220143231-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143231-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | BDNF, CD47, MAG | CYP3A4 2411/4885TDP1 1821/4885KDM4E 1726/4885 |
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | BDNF, CD47, MAG | CYP3A4 2411/4885TDP1 1821/4885KDM4E 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.