Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Furfural. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MASP2 | O00187 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furfural SCHEMBL19951030 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL653628 | 0.94 | ALDH1A1 (0.78) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL27941744 | 0.94 | ALDH1A1 (0.78) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL7162828 | 0.93 | ALDH1A1 (0.64) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL17671277 | 0.91 | ALDH1A1 (0.82) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL27822848 | 0.91 | ALDH1A1 (0.62) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL11853782 | 0.90 | ALDH1A1 (0.72) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL11853774 | 0.90 | ALDH1A1 (0.72) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL27188973 | 0.90 | ALDH1A1 (0.72) | ALDH1A1HCAR2MAPTPOLBTDP1 | |
| Furfural SCHEMBL28255155 | 0.89 | ALDH1A1 (0.78) | ALDH1A1HCAR2MAPTPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-88102048-A | Make other pollutant also reduce to the method for minimum reduction content of nitrogen oxide | — | 1988-12-21 | — | — | CN | claimed |
| CN-110040894-A | Method for treating low-concentration acetic acid wastewater containing mineral acid and organic impurities | 南京工业大学 | 2019-07-23 | — | — | CN | disclosed |
| EP-1600482-B1 | Liquid composition for metachromatic members, and its use | PILOT INK CO LTD (JP) | 2018-04-04 | — | — | EP | disclosed |
| CN-106146439-A | A kind of preparation method of furfural | 中国石油化工股份有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-103987432-B | The method and apparatus separating at least one carboxylic acid and furfural in the aqueous mixture dilute from it | 塔明克芬兰公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-103554068-B | The method of furfural prepared by a kind of vapor phase acid and Lewis acid altogether catalytic hydrolysis | Energy Institute Co., Ltd. of Henan Academy of Sciences (CN) | 2015-12-09 | — | — | CN | disclosed |
| WO-2015179243-A1 | SUGAR SEPARATION AND PURIFICATION THROUGH FILTRATION | SWEETWATER ENERGY, INC. (US) | 2015-11-26 | — | — | WO | disclosed |
| US-20150329927-A1 | Sugar Separation and Purification Through Filtration | APALTA TEHNOLOOGIA OÜ (EE) | 2015-11-19 | — | — | US | disclosed |
| WO-2014018450-A1 | IMPROVED ACETATE RESISTANCE IN YEAST BASED ON INTRODUCTION OF A MUTANT HAA1 ALLELE | EDENIQ, INC. (US) | 2014-01-30 | — | — | WO | disclosed |
| CN-102976539-A | Furfural production wastewater novel technology processing method | LISHU COUNTY YINTONG CHEMICAL CO LTD | 2013-03-20 | — | — | CN | disclosed |
| US-6093777-A | A CURED PRODUCT CONTAINING A THERMOSETTING RESIN AND A HYPERBRANCHED DENDRITIC MACROMOLECULE FORMED OF ESTER UNITS AS TOUGHENING AGENT | PERSTORP AB (SE) | 2000-07-25 | — | — | US | disclosed |
| EP-0449296-B1 | Palladium catalyzed carboalkoxylation of butadiene | DU PONT (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0449296-A1 | Palladium catalyzed carboalkoxylation of butadiene | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5026901-A | Producing alkyl pentenoate | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| CN-88102048-A | Make other pollutant also reduce to the method for minimum reduction content of nitrogen oxide | — | 1988-12-21 | — | — | CN | disclosed |
| EP-0271957-A2 | Process for treating coffee beans to make a better-tasting coffee | THE PROCTER & GAMBLE COMPANY (US) | 1988-06-22 | — | — | EP | disclosed |
| EP-0159754-A2 | Soluble coffee composition | THE PROCTER & GAMBLE COMPANY (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4280006-A | Process for the production of polyisocyanate silicate plastics utilizing an alkali metal cellulose silicate condensation product | BLOUNT DAVID H | 1981-07-21 | — | — | US | disclosed |
| US-4262108-A | FIREPROOF CONSTRUCTION MATERIALS, INSULATION | BLOUNT DAVID H | 1981-04-14 | — | — | US | disclosed |
| US-3987069-A | BORON PHOSPHATE CATALYST | PETRO-TEX CHEMICAL CORPORATION (US) | 1976-10-19 | — | — | US | disclosed |