Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.31 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724436 | 0.95 | MAPK14 (0.35) | MAPK14CYP2C9MAPK13BUB1PRKACG | |
| SCHEMBL2396457 | 0.86 | MAPK14 (0.41) | MAPK14CYP2C9MAPK13BUB1PRKACG | |
| SCHEMBL2441986 | 0.85 | MAPK13 (0.36) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1722786 | 0.84 | MAPK14 (0.40) | MAPK14CYP2C9MAPK13BUB1PRKACG | |
| SCHEMBL2394065 | 0.83 | — | — | |
| SCHEMBL3313067 | 0.78 | — | — | |
| SCHEMBL1725054 | 0.77 | MAPK14 (0.40) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394931 | 0.76 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2395459 | 0.76 | MAPK14 (0.41) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394923 | 0.76 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |