Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29526580 | 1.00 | CTSS (0.53) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL29526276 | 0.86 | CTSS (0.50) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL24420098 | 0.86 | CTSS (0.50) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL30492012 | 0.85 | CTSS (0.49) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL29526164 | 0.85 | CTSS (0.49) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL9744622 | 0.84 | CTSS (0.55) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL24420430 | 0.83 | CTSS (0.54) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL24420459 | 0.83 | CTSS (0.54) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL24420346 | 0.83 | CTSS (0.54) | CTSSCTSKKDM4EHTTALDH1A1 | |
| SCHEMBL29526431 | 0.83 | CTSS (0.54) | CTSSCTSKKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022099011-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |