Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29584197 | 1.00 | ACHE (0.41) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL24424317 | 0.94 | ACHE (0.41) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL25090694 | 0.93 | ACHE (0.40) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL24424394 | 0.91 | KDM5A (0.41) | ACHEBACE1CHEK1KDM5AKMT2A | |
| SCHEMBL29584222 | 0.91 | KDM5A (0.41) | ACHEBACE1CHEK1KDM5AKMT2A | |
| SCHEMBL29584160 | 0.90 | TLR9 (0.42) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL24424716 | 0.90 | TLR9 (0.42) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL24423105 | 0.89 | CHEK1 (0.37) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL24423703 | 0.89 | CHEK1 (0.37) | ACHEBACE1CHEK1KDM5ACHRM4 | |
| SCHEMBL29584970 | 0.89 | CHEK1 (0.37) | ACHEBACE1CHEK1KDM5ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635380-A | PPARgamma modulators and methods of use | 卫材R&D管理有限公司 | 2023-08-22 | — | — | CN | claimed |
| CN-116635380-A | PPARgamma modulators and methods of use | 卫材R&D管理有限公司 | 2023-08-22 | — | — | CN | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |