SCHEMBL24423814

SCHEMBL24423814

COc1cc(-c2cc(C(=O)N3CCC(C(=O)N[C@H]4CC[C@@H](C)CC4)CC3)n[nH]2)c(F)cn1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ KDM5A P29375 18/20 0.43
▸ KDM5B Q9UGL1 2/20 0.42
▸ KDM5C P41229 1/20 0.42
▸ KDM4C Q9H3R0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24423815 1.00 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24423816 1.00 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24424023 0.91 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL29583248 0.91 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24424022 0.91 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24424020 0.91 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24422908 0.90 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24422907 0.90 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL24422906 0.90 MEN1 (0.46) MEN1ALDH1A1KMT2AKDM5AKDM5B
SCHEMBL29586603 0.90 KDM5A (0.42) MEN1ALDH1A1KMT2AKDM5AKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116635380-A PPARgamma modulators and methods of use 卫材R&D管理有限公司 2023-08-22 — — CN disclosed
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-03-02 — — US disclosed
WO-2022099144-A1 ΡΡΑRγ MODULATORS AND METHODS OF USE Eisai R&D Mangement Co., Ltd. (JP) 2022-05-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE PPARG, PPARA, PPARD MEN1 4809/4885ALDH1A1 542/4885KMT2A 4267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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