SCHEMBL2442428

SCHEMBL2442428

COC(=O)c1cccc(C)c1S(=O)(=O)NC(=O)Nc1nc(OCC(F)(F)F)nc(N(C)C)n1.Cc1cccc(C(=O)O)c1S(=O)(=O)NC(=O)Nc1nc(OCC(F)(F)F)nc(N(C)C)n1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
MAPT P10636 1/20 0.36
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CFTR P13569 1/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
USP2 O75604 1/20 0.34
KDM4E B2RXH2 1/20 0.34
NPC1 O15118 1/20 0.34
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL55457 0.97 MEN1 (0.38) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL29577044 0.97 MEN1 (0.38) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL30748262 0.97 MEN1 (0.38) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL15524981 0.96 MEN1 (0.38) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL29415215 0.96 MEN1 (0.39) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL55458 0.96 MEN1 (0.39) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL15152277 0.93 MEN1 (0.36) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
Sulfuric Acid SCHEMBL23531082 0.92 ALDH1A1 (0.36) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL8860956 0.90 MEN1 (0.43) MEN1KMT2AMAPTALDH1A1SMN1; SMN2
Triforine SCHEMBL15553097 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3062619-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS DOW AGROSCIENCES LLC (US) 2019-07-24 EP disclosed
EP-3092310-A1 RNA-GUIDED GENE DRIVES President and Fellows of Harvard College (US) 2016-11-16 EP disclosed
WO-2015105928-A9 RNA-GUIDED GENE DRIVES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-09-24 WO disclosed
WO-2015105928-A1 RNA-GUIDED GENE DRIVES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-07-16 WO disclosed
EP-2547766-A2 HERBICIDE-TOLERANT PLANTS BASF Agrochemical Products, B.V. (NL) 2013-01-23 EP disclosed
WO-2011114232-A2 HERBICIDE-TOLERANT PLANTS BASF AGROCHEMICAL PRODUCTS B.V. (NL) 2011-09-22 WO disclosed