Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183945 | 0.84 | GRM5 (0.33) | GRM5ROCK2ROCK1 | |
| SCHEMBL24423442 | 0.83 | CYP2C19 (0.35) | GRM5ROCK2ROCK1 | |
| SCHEMBL22993388 | 0.81 | DRD2 (0.33) | GRM5ROCK2ROCK1 | |
| SCHEMBL24253264 | 0.80 | CSF1R (0.33) | GRM5ROCK2ROCK1 | |
| SCHEMBL173333 | 0.77 | HRH4 (0.36) | ROCK2ROCK1 | |
| SCHEMBL24253251 | 0.76 | — | — | |
| SCHEMBL30755929 | 0.73 | HDAC6 (0.32) | ROCK2ROCK1 | |
| SCHEMBL14925516 | 0.71 | DRD2 (0.35) | ROCK2ROCK1 | |
| SCHEMBL24077537 | 0.71 | — | — | |
| SCHEMBL24424398 | 0.71 | CSF1R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |