Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24424556 | 0.89 | STAT3 (0.38) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL19905723 | 0.81 | DNMT1 (0.34) | SMN1; SMN2ALDH1A1LMNAHTTSTAT3 | |
| SCHEMBL18047923 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1STAT3 | |
| SCHEMBL13453046 | 0.69 | STAT3 (0.38) | SMN1; SMN2ALDH1A1LMNAHTTSTAT3 | |
| SCHEMBL17049 | 0.69 | KMT2A (0.40) | SMN1; SMN2ALDH1A1STAT3DNMT1BCHE | |
| SCHEMBL25487728 | 0.68 | STAT3 (0.39) | SMN1; SMN2ALDH1A1LMNAHTTRAB9A | |
| SCHEMBL29906344 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1LMNAHTTSTAT3 | |
| SCHEMBL24424690 | 0.67 | NPC1 (0.34) | SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL7949968 | 0.67 | CYP2D6 (0.41) | SMN1; SMN2ALDH1A1STAT3ACHE | |
| SCHEMBL17869 | 0.67 | KMT2A (0.41) | SMN1; SMN2ALDH1A1LMNAHTTSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |