Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13453046 | 0.88 | STAT3 (0.38) | STAT3CA12CA1CA9CYP1A2 | |
| SCHEMBL24424558 | 0.81 | SMN1; SMN2 (0.33) | DNMT1STAT3ALDH1A1LMNAHTT | |
| SCHEMBL16035308 | 0.76 | KMT2A (0.39) | STAT3CA12CA1CA9CYP1A2 | |
| SCHEMBL18047923 | 0.72 | SMN1; SMN2 (0.46) | STAT3G6PDCA12CA1CA9 | |
| SCHEMBL29906344 | 0.71 | SMN1; SMN2 (0.42) | STAT3CA12CA1CA9CYP1A2 | |
| SCHEMBL11637311 | 0.70 | KMT2A (0.47) | STAT3CA12CA1CA9CYP1A2 | |
| SCHEMBL15362867 | 0.69 | KMT2A (0.37) | STAT3CA12CA1CA9ALDH1A1 | |
| SCHEMBL690833 | 0.68 | STAT3 (0.40) | STAT3CA12CA1CA9CYP1A2 | |
| SCHEMBL7849587 | 0.68 | KMT2A (0.50) | STAT3CA12CA1CA9ALDH1A1 | |
| SCHEMBL29835367 | 0.68 | VDR (0.41) | STAT3CA12CA1CA9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684880-B1 | DISPIROPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-02-28 | — | — | EP | disclosed |