Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | HTR6 | P50406 | 3/20 | 0.64 |
| ▸ | CDK4 | P11802 | 6/20 | 0.61 |
| ▸ | CCND1 | P24385 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 1/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.61 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27191681 | 0.86 | CDK4 (0.66) | HTR1AHTR6CDK4CCND1HTR2A | |
| SCHEMBL29164960 | 0.84 | HTR1A (0.71) | TRPM8TRPV1HTR1AHTR6CDK4 | |
| N,N-Dimethyltryptamine SCHEMBL31289392 | 0.80 | HTR1A (0.78) | HTR1AHTR6CDK4CCND1HTR2A | |
| N,N-Dimethyltryptamine SCHEMBL30785193 | 0.80 | HTR1A (0.78) | HTR1AHTR6CDK4CCND1HTR2A | |
| SCHEMBL13994256 | 0.80 | HTR1A (0.72) | TRPM8TRPV1HTR1AHTR6CDK4 | |
| Indolylpropionic Acid SCHEMBL29521227 | 0.80 | MAPT (0.68) | HTR6CDK4HTR2AHTR2CHTR1B | |
| Indolylpropionic Acid SCHEMBL29374161 | 0.80 | MAPT (0.68) | HTR6CDK4HTR2AHTR2CHTR1B | |
| Indolylpropionic Acid SCHEMBL195405 | 0.80 | MAPT (0.68) | HTR6CDK4HTR2AHTR2CHTR1B | |
| SCHEMBL14631588 | 0.79 | CDK4 (0.61) | TRPM8TRPV1HTR1AHTR6CDK4 | |
| SCHEMBL14705330 | 0.79 | HTR1A (0.83) | TRPM8TRPV1HTR1AHTR6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |
| WO-2011107948-A2 | LIGANDS OF INSULIN DEGRADING ENZYME AND THEIR USES | UNIVERSITE LILLE 2 DROIT ET SANTE (FR) | 2011-09-09 | — | — | WO | disclosed |