Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24424896 | 1.00 | JAK2 (0.47) | JAK2JAK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL29584570 | 0.85 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL29585681 | 0.85 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL20980264 | 0.83 | JAK2 (0.53) | JAK2JAK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL20959554 | 0.83 | JAK2 (0.53) | JAK2JAK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL20980265 | 0.83 | JAK2 (0.53) | JAK2JAK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL30532531 | 0.82 | JAK2 (0.52) | JAK2JAK1KMT2AHSD11B1GPR119 | |
| SCHEMBL30390101 | 0.81 | JAK2 (0.45) | JAK2JAK1KMT2AHSD11B1TACR1 | |
| SCHEMBL30199770 | 0.81 | JAK2 (0.45) | JAK2JAK1KMT2AHSD11B1TACR1 | |
| SCHEMBL30199746 | 0.79 | JAK2 (0.46) | JAK2JAK1KMT2AHSD11B1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |