Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.76 |
| ▸ | LIFR | P42702 | 3/20 | 0.71 |
| ▸ | PPARD | Q03181 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21636802 | 1.00 | NR1H4 (0.76) | NR1H4LIFRPPARD | |
| SCHEMBL24425702 | 1.00 | NR1H4 (0.76) | NR1H4LIFRPPARD | |
| SCHEMBL24425717 | 0.96 | NR1H4 (0.75) | NR1H4LIFRPPARD | |
| SCHEMBL24425718 | 0.92 | NR1H4 (0.79) | NR1H4LIFR | |
| SCHEMBL24425700 | 0.92 | NR1H4 (0.73) | NR1H4LIFRPPARD | |
| SCHEMBL21636808 | 0.89 | NR1H4 (0.77) | NR1H4LIFRPPARD | |
| SCHEMBL24425720 | 0.88 | NR1H4 (0.89) | NR1H4LIFRPPARD | |
| SCHEMBL24425716 | 0.88 | NR1H4 (0.94) | NR1H4LIFRPPARD | |
| SCHEMBL28530665 | 0.86 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL30080655 | 0.86 | NR1H4 (0.94) | NR1H4LIFRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332450-B2 | Isoxazole as FXR receptor agonists | BAR PHARMACEUTICALS SOCIETA' A RESPONSABILITA' LIMITATA (IT) | 2022-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332450-B2 | Isoxazole as FXR receptor agonists | NR1H4, FXR1, GPBAR1 | NR1H4 1/4885LIFR 1640/4885PPARD 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.