Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.34 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.34 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.34 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876260 | 0.82 | BTK (1.00) | BTKEPHX2P2RX7JAK2CYP3A4 | |
| SCHEMBL16793886 | 0.79 | BTK (0.66) | BTKEPHX2P2RX7JAK2CYP3A4 | |
| SCHEMBL16794015 | 0.75 | BTK (0.60) | BTKEPHX2P2RX7 | |
| SCHEMBL16794073 | 0.73 | BTK (0.83) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL28125942 | 0.72 | BTK (0.54) | BTKEPHX2P2RX7 | |
| SCHEMBL16794271 | 0.71 | BTK (0.59) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL16793991 | 0.71 | BTK (0.71) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL16793836 | 0.71 | BTK (0.74) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL18170489 | 0.71 | BTK (0.70) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL16793906 | 0.70 | BTK (0.71) | BTKJAK2CYP3A4HRH2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500569-B1 | 2-OXO-IMIDAZOPYRIDINES AS REVERSIBLE BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-05-18 | — | — | EP | disclosed |