⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538676 | 0.76 | — | — | |
| SCHEMBL20730465 | 0.74 | — | — | |
| SCHEMBL13424856 | 0.69 | TSHR (0.35) | — | |
| SCHEMBL23701012 | 0.69 | — | — | |
| SCHEMBL7181757 | 0.68 | TSHR (0.39) | — | |
| SCHEMBL38309 | 0.68 | — | — | |
| SCHEMBL14204 | 0.68 | — | — | |
| SCHEMBL8737498 | 0.67 | — | — | |
| SCHEMBL22413533 | 0.67 | — | — | |
| SCHEMBL18125617 | 0.67 | TSHR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724191-B9 | 5-(2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)-3-(1H-PYRAZOL-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS AS TRK KINASE INHIBITORS FOR TREATING CANCER | PYRAMID BIOSCIENCES INC (US) | 2022-05-18 | — | — | EP | disclosed |