Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 14/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 6/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485242 | 0.73 | PDPK1 (1.00) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL421269 | 0.73 | JAK2 (0.77) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL24427513 | 0.73 | JAK2 (0.53) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL6492377 | 0.72 | JAK2 (0.69) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL3361070 | 0.71 | JAK2 (1.00) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL12907241 | 0.71 | JAK2 (1.00) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL6480460 | 0.71 | PDPK1 (0.65) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL989969 | 0.71 | ASIC3 (0.51) | ASIC3MAPTNPSR1CYP11B1CYP11B2 | |
| SCHEMBL6479941 | 0.70 | JAK2 (0.72) | PDPK1JAK2TGFBR1AURKAAURKB | |
| SCHEMBL6488855 | 0.70 | JAK2 (0.72) | PDPK1JAK2TGFBR1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998263-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2022-05-18 | — | — | EP | disclosed |