Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 10/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24428829 | 0.89 | CHRM2 (0.33) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL24429015 | 0.84 | NOS3 (0.43) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL27012448 | 0.84 | CHRM2 (0.33) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL23696509 | 0.83 | CYP2D6 (0.42) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL27360431 | 0.82 | CHRM2 (0.32) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL24508748 | 0.81 | CHRM2 (0.32) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL12794001 | 0.81 | CHRM1 (0.39) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL26405377 | 0.79 | CHRM2 (0.33) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL25594142 | 0.79 | CHRM2 (0.33) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL24233216 | 0.79 | CHRM1 (0.36) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4105203-A1 | SPIRO-CONDENSED INDOLE COMPOUNDS AS EHMT2 INHIBITORS | Epizyme Inc (US) | 2022-12-21 | — | — | EP | disclosed |
| EP-3519393-B1 | SUBSTITUTED FUSED BI- OR TRI- HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS | EPIZYME INC (US) | 2022-05-18 | — | — | EP | disclosed |