Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028806 | 1.00 | KDM4E (0.41) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL12285829 | 0.81 | SMN1; SMN2 (0.50) | POLBKMT2AMEN1SIGMAR1 | |
| SCHEMBL21743266 | 0.80 | SMN1; SMN2 (0.44) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL21941855 | 0.80 | SMN1; SMN2 (0.44) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL17828077 | 0.79 | SIGMAR1 (0.55) | KMT2AMEN1TSHRSIGMAR1ALDH1A1 | |
| SCHEMBL24428715 | 0.78 | KMT2A (0.37) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL9407486 | 0.78 | KMT2A (0.55) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL21667814 | 0.77 | MAPK1 (0.40) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL21667816 | 0.77 | MAPK1 (0.40) | KDM4EPOLBKMT2AMEN1ATM | |
| SCHEMBL21667815 | 0.77 | MAPK1 (0.40) | KDM4EPOLBKMT2AMEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519393-B1 | SUBSTITUTED FUSED BI- OR TRI- HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS | EPIZYME INC (US) | 2022-05-18 | — | — | EP | disclosed |